Evaluation of DNA versus collagen perception in scientific articles examining cancer chemotherapy: Implication for collagen-based approaches

Objective: Although cancer chemotherapy has been used for more than seventy years, its definitive mechanism of action is not known. Many studies indicate that beyond DNA the collagen connective tissue matrix also affected. This database analysis aims to determine extent versus perception in scientific papers indexed under PubMed. Materials and methods: The PubMed scanned on September, 15, 2021 using following keywords combinations; "cancer", "cancer chemotherapy", AND damage”, “chemotherapy "chemotherapy clinical" as nominator. number items found each search was proportioned terms “DNA collagen” ratio accepted shift coefficient. Results: Tested with p1-p2 calculate difference between two proportions both items. Based main rule assumption “all cells have all live matrix”. In data, a significant (p <0.001) obtained dichotomy scans. Conclusion: data supports argument DNA-based rather collagen, since synthesis degradation process very slow; it possible observe short term studies. Chemotherapy should be further analyzed by this manner purpose matrix.